AIGUADE BOSCH, JOSE,GUAL ROIG, SILVIA,PRAT QUINONES, MARIA,PUIG DURAN, CARLOS
申请号：
PE0005142014
公开号：
PE12312014A1
申请日:
2012.11.09
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to cyclohexylamine derivative compounds of formula (a) wherein R1 and R2 are each h, alkyl (c1-c4), alkoxy (c1-c4), among others R3 is a compound of formula (i) or (ii), where r is H, alkyl Hydroxy (C1 - C4), among others R5 is cycloalkyl, aryl (C3 - C8) (c5-c6), among others, R6 is Ari (C5, C6) heteroaryl of 5 to 6 members, alquenilo (C2, C8), among others Q is a direct link.- CH2 -, - CH2 CH2, among others b is a rest which has binding activity of beta2 adrenergic l is a Covalent Linker.Preferred compounds are Hydroxy (di - (2-thienyl) acetate trans-4 - [3 - [6 - ({{[(2R) - 2 - hydroxy - 2 - 8 - hydroxy - 2 - oxo - 1.2 - dihidroquinolin - 5 - il) ethyl] amino} - 2 - methyl) oxo - 1.3 - benzoxazole - 3 (2H) - il}] propyl Cyclohexyl (methyl) amino] -, dihidrofluoruro Hydroxy (di - (2-thienyl) Trans - 4 - [3 - [5 - ({{[(2R) - 2 - hydroxy - 2 (- 8 - hydroxy - 2 - oxo - 1.2 - dihidroquinolin - 5 - yl) methyl) ethyl] amino} - 2 - oxo - 23 -] - 1H benzimidazole - triazin-1-yl] propyl Cyclohexyl (methyl) amino]}, dihidrofluoruro among others. It also relates to a Pharmaceutical composition. These compounds are \ufffd2 adrenergic agonists and antagonists of Muscarinic m3 being useful in the treatment of pulmonary disease, glaucoma, asthmaSE REFIERE A COMPUESTOS DERIVADOS DE CICLOHEXILAMINA DE FORMULA (A) DONDE R1 Y R2 SON CADA UNO H, ALQUILO(C1-C4), ALCOXI(C1-C4), ENTRE OTROS R3 ES UN COMPUESTO DE FORMULA(i) O (ii), DONDE R4 ES H, HIDROXI, ALQUILO(C1-C4), ENTRE OTROS R5 ES CICLOALQUILO(C3-C8), ARILO(C5-C6), ENTRE OTROS R6 ES ARILO(C5-C6), HETEROARILO DE 5 A 6 MIEMBROS, ALQUENILO(C2-C8), ENTRE OTROS Q ES UN ENLACE DIRECTO, -CH2-, CH2-CH2, ENTRE OTROS B ES UN RESTO QUE TIENE ACTIVIDAD DE UNION BETA2-ADRENERGICA L ES UN ENLAZADOR COVALENTE. SON COMPUESTOS PREFERIDOS: HIDROXI(DI-2-TIENIL)ACETATO DE TRANS-4-[{3-[6-({[(2R)-2-HIDROXI-2-(8-HIDROXI-2-OXO-1,2-DIHIDROQUINOLIN-5-IL)ETIL]AMINO}METIL)-2-OXO-1,3-BENZOXAZOL-3(2H)-IL]PROPIL}(METIL)AMINO]-CICLOHEXILO, DIHIDROFLUORURO
