Pyrimidinones as PI3K inhibitors

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专利权人:

INCYTE CORPORATION

发明人:

LI, YUN-LONG,METCALF, BRIAN W.,COMBS, ANDREW P.

申请号：

ES10729035

公开号：

ES2486715T3

申请日:

2010.06.28

申请国别(地区):

ES

年份:

2014

代理人:

摘要：

A compound of formula IId: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: A is aryl, heteroaryl, cycloalkyl or heterocycloalkyl, each optionally substituted with 1, 2, 3, 4 or 5 independently selected substituents halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halosulfanyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, CN, NO2, ORa, SRa, C (O) Rb, C (O ) NRcRd, C (O) ORa, OC (O) Rb, OC (O) NRcRd, NRcRd, NRcC (O) Rb, NRcC (O) ORa, NRcC (O) NRcRd, C (>； = NRe) Rb, C (>； = NRe) NRcRd, NRcC (>； = NRe) NRcRd, NRcS (O) Rb, NRcS (O) 2Rb, NRcS (O) 2NRcRd, S (O) Rb, S (O) NRcRd, S (O) 2Rb and S (O) 2NRcRd； wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl or heterocycloalkyl optionally is substituted with 1, 2, 3, 4 or 5 substituents independently selected from halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halosulfanyl, CN, NO2, ORa, SRa, C (O) Rb, C (O) NRcRd, C (O) ORa, OC (O) Rb, OC (O) NRcRd, C (>； = NRe) NRcRd, NRcC (>； = NRe) NRcRd, NRcRd, NRcC (O) Rb, NRcC (O) ORa, NRcC (O) NRcRd, NRcS (O) Rb, NRcS (O ) 2Rb, NRcS (O) 2NRcRd, S (O) Rb, S (O) NRcRd, S (O) 2Rb and S (O) 2NRcRd； R1 is NRARB； R2a is H, halogen, OH, CN, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl, wherein said C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2 or 3 independently selected halogen substituents, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halosulfanyl, CN, NO2, ORa2SRa2, C (O) Rb2, C (O) NRc2Rd2, C (O) ORa2, OC (O) Rb2, OC (O) NRc2Rd2, C (>； = NRe) NRc2Rd2, NRc2C (>； = NRe) NRc2Rd2, NRc2Rd2, NRc2C (O) Rb2, NRc2C (O) ORa2, NRc2C (O) NRc2Rd2, NRc2S (O) NRc2S (O) 2Rb2, NRc2S (O) 2NRc2Rd2, S (O

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