您的位置: 首页 > 农业专利 > 详情页

Benzamides substituted with activity towards EP4 receptors
专利权人:
Draconis Pharma; S.L.
发明人:
VIRGILI BERNADO, Marina,CARCELLER GONZALEZ, Elena,SALAS SOLANA, Jordi
申请号:
ES14706498
公开号:
ES2615742T3
申请日:
2014.02.07
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compound of general formula (I): ** Formula ** in which: each R1 can be a -COOH; an H; a halogen; a tetrazole; a -SO2-NH-C (>; = O) -R '; a -C (>; = O) NH-SO2-R '; or a -SO2-OH with the proviso that only one of them should always represent a -COOH; or tetrazol or -SO2-NH-C (>; = O) -R 'or -C (>; = O) NH-SO2-R' or -SO2-OH, each R2 is independently selected from the group consisting of H; a halogen; C1-6 alkyl; or -O-C1-6 alkyl, with the proviso that at least one R2 must be different from H R3 is selected from H; or a C1-6 alkyl; R4 is a halogen or a C1-6 alkyl; A, B and C independently represent a CRa or an N; And it is a -NR5R6; a -OR7; a phenyl, optionally substituted with at least one Rb; a benzyl optionally substituted with at least one Rb; a 5- or 6-membered heterocyclic ring, optionally substituted with at least one Rb, containing at least one heteroatom selected from N, O or S; a C1-4 alkylene-C3-6 cycloalkyl; or a C1-6 alkyl; R5 and R6 are independently selected from H; a C1-6 alkyl; a benzyl; a C3-6 cycloalkyl; -C1-4-C3-6 cycloalkyl; or -C 1-4 alkyl-C 1-6 alkyloxy; R7 is an H, a C1-6 alkyl, a benzyl optionally substituted with at least one Rc; or a C1-4alkylC3-6 cycloalkyl; R 'is independently selected from a hydrogen; C1-6 alkyl; an optionally substituted phenyl; or -N (CH3) 2; Ra is an H or a C1-6 alkyl; each Rb is independently an H; a C1-6 alkyl; a halogen; a -CN; a trihalo-C1-6 alkyl; a -CONR8R9; a -OR10 or -C1-4-OR11 alkylene; each Rc is independently an H; a C1-6 alkyl; or a halogen; R8 and R9 are independently selected from H; or a C1-6 alkyl; R10 and R11 are independently selected from H; or a C1-6 alkyl; with the proviso that when R1 is COOH in the meta position and R2 is either methyl or Cl or when R1 is COOH in the para position and R2 is methyl, R7 is not methyl and R4 is not Br and with the proviso that when R1 tetrazol is the circumstances in which Y is methoxy or pyrrolinyl and R4 is Br or Cl are not possible, and the salts and solvat
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充