BEAUDOIN, SERGE,JOHNSON, MATTHEW SCOTT,MARRON, BRIAN EDWARD,SUTO, MARK J.
申请号：
ES08781823
公开号：
ES2523196T3
申请日:
2008.07.14
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound according to Formula I: ** Formula ** or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R4, R5 and R6 are each independently selected from H, halogen, alkyl of C1-8, aryl, heteroaryl or heterocycloalkyl, in which two or more elements selected from R1, R2, R3, R4, R5 and R6 are optionally joined to form a 4-8 element carbocyclic or heterocyclic ring having from 1-3 heteroatoms as ring elements selected from O, N or S； R7 is an element selected from C1-8 alkyl, heterocycloalkyl, aryl and heteroaryl, with the proviso that R7 is other than methyl, and R7 is not attached to the S (O) 2 moiety of Formula (I) via a bond sulfuritrogen； wherein the aliphatic portion of the groups R1, R2, R3, R4, R5, R6, R7 is optionally substituted with from 1-3 Ra substituents selected from the group consisting of -ORb,>； = O,>； = NRb, >； = N-ORb,>； = NRbRb, -SRb, - halogen, -Si (Rb) 3, -OC (O) Rb, -C (O) Rb, -CO2Rb, -CON (Rb) 2, -OC ( O) N (Rb) 2, -NRbC (O) Rb, -NRb-C (O) N (Rb) 2, - NRbC (O) 2Rb, -NRb-C (NRbRb)>； = NRb, -S (O ) Rb, -S (O) 2Rb, -S (O) 2N (Rb) 2, -NRSO2Rb, C1-8 alkyl, -Rb, -CN and -NO2, wherein each Rb is independently H, alkyl of C1-8, aryl or heteroaryl and two Rb groups when attached to the same nitrogen atom are optionally combined together with the nitrogen atom to which they are attached to form a ring of 5-6 elements having from 0-2 additional heteroatoms as elements of the ring selected from O, N or S； in which each Rb group is further optionally substituted with from 1-3 Rc substituents selected from -ORd,>； = O,>； = NRd,>； = N-ORd,>； = NRdRd, -SRd, - halogen, -Si (Rd ) 3, -OC (O) Rd, -C (O) Rd, -CO2Rd, -CON (Rd) 2, -OC (O) N (Rd) 2, -NRdC (O) Rd, -NRd-C ( O) N (Rd) 2, - NRdC (O) 2Rd, -NRd-C (NRdRd)>； = NRd, -S (O) Rd, -S (O) 2Rd, -S (O) 2N (Rd) 2 , -NRSO2Rd, C1-8 alkyl, -CN and -NO2, in which each Rd is H, C1-8 alkyl or aryl and two Rd groups when attached to the same nitrogen atom are optionally combined
