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Macrolide derivatives, their preparation and therapeutic use
专利权人:
SANOFI
发明人:
BAURIN, Nicolas,BENEDETTI, Yannick,BOULEY, Emmanuel,ZHANG, Jidong
申请号:
ES13776739
公开号:
ES2598079T3
申请日:
2013.09.16
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compound of formula (I): ** Formula ** in which: - Y represents a hydrogen atom, a group - (C>; = O) -NR2R3 or a group - (C>; = O) -O-R18; - Z represents: - a hydrogen atom, - a C1-6 alkyl group, which is unsubstituted or substituted with one or more R4 groups, - a C3-7 cycloalkyl group, which is unsubstituted or substituted with a group -NH- (C>; = O) -R19 or with a group -NH-SO2-R20, - a group -heterocycloalkyl of C3-6, - a group -NH- (C>; = O) -R5 ; - R 1 represents a hydrogen atom, a C 2-6 alkenyl group, a C 2-6 alkynyl group or a C 1-6 alkyl group, which is unsubstituted or substituted with a C 1 -luoroalkyl group. 4 or with a heteroaryl group which is unsubstituted or substituted with a 3- (3-fluorophenyl) -2-oxo-1,3-oxazolidin-5-ylmethyl group; - R2 represents a hydrogen atom or a C1-6 alkyl group; - R3 represents: - a C3-7 -cycloalkyl group, which is unsubstituted or substituted with a C1-3alkyl group substituted with a -NH-SO2-R21 group, - a heteroaryl group, - an alkyl group C1-6 linear or branched, which is unsubstituted or substituted with a group selected from: - a group -NH-R6, - a group -NH-SO2-R7, - a group -NH- (C>; = O ) -R8, - a C3-7 cycloalkyl group, which is unsubstituted or substituted with a C3-6 heterocycloalkyl group, - a C3-6 heterocycloalkyl group, - an aryl group, which is not substituted or substituted with one or more groups independently selected from a halogen atom and a C1-4 fluoroalkyl group, - a heteroaryl group, which is unsubstituted or substituted with a C1-3alkyl group, a group - C1-4 alkoxy, a C1-4 fluoroalkyl group or a C3-6 heterocycloalkyl group, - or alternatively with one or more C1-4alkoxy groups; or alternatively, R2 and R3, together with the nitrogen atom to which they are attached, constitute a C3-6 heterocycloalkyl group selected from: aziridine, azetidine, pyrrolidine, piperidine, morpholine, thiomorpholine or piperazine; said heterocycloalkyl group being unsubstituted or substituted with a heteroaryl grou
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