您的位置: 首页 > 农业专利 > 详情页

New derivatives of (aza) benzidril ether, method of preparation thereof and use thereof as ligands of the H4 receptor for therapeutic applications
专利权人:
BIOPROJET
发明人:
Berrebi-Bertrand, Isabelle,Billot, Xavier,Calmels, Thierry,Capet, Marc,Krief, Stéphane,Labeeuw, Olivier,Lecomte, Jeanne-Marie,Levoin, Nicolas,Ligneau, Xavier,Robert, Philippe,Schwartz, Jean-Charles
申请号:
ES13170687
公开号:
ES2606381T3
申请日:
2013.06.05
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compounds of formula (I): ** Formula ** R1 represents a C1-C6 alkyl; Het represents a 3- to 7-membered non-aromatic monocyclic heterocycle containing one nitrogen atom and, optionally, 1 to 3 additional heteroatoms chosen from O, S, in which said nitrogen atom is attached to R1; A represents a single bond or a C1-C6 alkyl group; Each identical or different R2, R3, R4, R5, R6 is independently chosen from: * hydrogen * halo; azido; cyano; hydroxy; nitro; * I rent; alkoxy; alkylsulfanyl; alkenyl; alkynyl; alkenyloxy; alkenyloxy; alkenylsulfanyl; alkynylsulfanyl; cycloalkoxy; cycloalkylalkyl; whose alkyl, alkenyl, alkynyl or cycloalkyl part may be substituted with one or more of halo, hydroxy, polyhydroxy, alkoxy, hydroxyalkoxy, cyano, amino, aminoalkyl, alkylamino, dialkylamino, aminoalkylamino, aminoalkylaminocarbonyl, alkoxycarbonylamino, diarylmethylimino (where aryl is optionally substituted with one or more of hydroxy or halo), cycloalkenylimino (where cilalkenyl is optionally substituted with one or more of alkyl, OH), alkylsulfanyl, alkylsulfinyl, alkylsulfonyl, cycloalkyl, cycloalkenyl, guanidin, guanidino, alkylcarbonylguanidino, guanidino, guanidino , alkoxycarbonyl, alkoxycarbonylakylamino, alkoxycarbonylalkylcycloalkyl, alkoxycarbonylheterocyclyl, aminocarbonyl, alkylaminocarbonyl, alkylcarbonyl, alkylcarbonylalkyoxy, aryloxy, arylsulfanyl (heteroaryl, heteroaryl, heterocyl) or more of oxo, amino, imino), heteroaryloxy, heterocyclyloxy, heteroarylamino, heterocyclylamino, hydrazinocarbonyl, hydroxyalkylcycloalkyl, N-alkyl (thioureido), phthalimido, ureido, oxocycloalkenylamino substituted with amino, carbamimidoylheterocyclyl; * Not me; alkylamino; alkylcarbonyl; alkoxycarbonyl; alkylsulfanyl; alkylsulfinyl; alkylsulfonyl; alkylsulfonyloxy in which: alkyl can be substituted with one or more halo; and at least one of R2, R3, R4, R5, R6 is different from H each Xi, identical or different is chosen from -N>; =, -C (Ri)>; = and -C (Ri ')>; =, i represents
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充