A compound represented by the following general formula (I) which has ADAM17 inhibitory activity, or a salt thereof, or a solvate thereof: wherein X represents a phenylene group； Y represents a hydrogen atom, -(CH2)mR1 or the like； R1 represents -NR5COR2, -NR5SO2R2 or -NR3R4； R2 represents a C1-C6 alkyl group, an aryl group, or a C1-C6 alkoxy group； R3 and R4 represent a C1-C6 alkyl group and the like； R5 represents a hydrogen atom or a C1-C6 alkyl group or the like； m indicates an integer of from 0 to 4； and Z represents a hydrogen atom or a C1-C6 alkyl group.本發明係一種以下述通式(I)所表示之表現ADAM17抑制作用之化合物或其鹽、或該等之溶劑合物。[式中，X表示亞苯基；Y表示氫原子或-(CH2)mR1等；R1表示-NR5COR2、-NR5SO2R2或-NR3R4；R2表示C1~C6之烷基、芳基或C1~C6之烷氧基；R3及R4表示C1~C6之烷基等；R5表示氫原子或C1~C6之烷基等；m表示0~4之任意整數；Z表示氫原子或C1~C6之烷基]。
