Marcelis van der Stelt,Joseph Maria Gerardus Barbara Cals,Johannes Petrus Gerardus Klomp
申请号：
US12628538
公开号：
US08143246B2
申请日:
2010.02.15
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivative having the general Formula Iwherein R1 is H, (C1-6)alkyl (optionally substituted with oxo, (C1-3)alkyloxy, (C1-3)alkyloxycarbonyl, halogen or CN), (C3-6)cycloalkyl or (C3-6)cycloalkyl(C1-3)alkyl, each cycloalkyl ring optionally comprising a heteroatom selected from O and S R2 and R3 are independently H or (C1-3)alkyl or R2 and R3 form together with the carbon atom to which they are bound a (C3-5)cycloalkyl group R4 is H or 1 to 3 F substituents R5 is H or 1 to 4 F substituents R6 and R7 are independently H or F X represents R8, OR8, NR8R9,R8 is (C5-7)cycloalkyl optionally comprising a heteroatom selected from O, S, SO and SO2 R9 is H or (C1-4)alkyl R10 represents 1-3 substituents independently selected from H, (C1-3)alkyl, halogen, oxo, CN and CF3 Y is CF2, O, S, SO or SO2 or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of said 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives in the treatment of pain such as for example peri-operative pain, chronic pain, neuropathic pain, cancer pain and pain and spasticity associated with multiple sclerosis.
