A compound of formula I or a stereoisomer, tautomer, racemic, salt, hydrate, N-oxide form, or solvate thereof, wherein A1 and A2 are selected from C and N； in which when A1 is C, then A2 is N； and in which when A2 is C, then A1 is N； R1 and R7 are each independently selected from -H, -halo, -OH, -C1-6 alkyl, -O-C1-6 alkyl, -S-C1-6 alkyl, - NR9R10, - (C>； = O) -R4, -SO2-R4, -CN, -NR9-SO2-R4, -C3-6cycloalkyl, and -Het6； wherein each of said -C1-6 alkyl is optionally and independently substituted with from 1 to 3 substituents selected from -halo, -OH, -NR11R12, -C1-6 alkyl, and -S-C1-6 alkyl； R 2 is selected from -H, -halo, -OH, -C 1-6 alkyl, -O-C 1-6 alkyl, -S-C 1-6 alkyl, - (C>； = O) -C 1-6 alkyl, - ( C>； = O) -O-C1-6 alkyl, - (C>； = O) -NR27R28, -Het3, - (C>； = O) -Het3, -SO2-C1-6 alkyl, and -C3-6 cycloalkyl ； wherein each of said -C1-6 alkyl is optionally and independently substituted with from 1 to 3 substituents selected from -halo, -OH, -O-C1-6 alkyl, -S-C1-6 alkyl, -Het3, -Ar2, and -NR13R14； R3 is selected from -H, -halo, -OH, -C 1-6 alkyl, -O-C 1-6 alkyl, -S-C 1-6 alkyl, - (C>； = O) -C 1-6 alkyl, - ( C>； = O) -O-C1-6 alkyl, -Het2, -C3-6 cycloalkyl - (C>； = O) -Het2, - (C>； = O) -NR29R30, and -SO2-C1-6 alkyl； wherein each of said -C1-6 alkyl is optionally and independently substituted with from 1 to 3 substituents selected from -halo, -OH, -O-C1-6 alkyl, -S-C1-6 alkyl, -NR15R16, -Het2, and -Ar3； R4 is independently selected from -halo, -OH, -C 1-6 alkyl, -O-C 1-6 alkyl, -S-C 1-6 alkyl, -NR17R18, and -Het4； R5 is selected from -H, -C 1-6 alkyl, -C 3-6 cycloalkyl； wherein each of said C1-6 alkyl or -C3-6 cycloalkyl is optionally and independently substituted with from 1 to 3 substituents selected from -halo, -OH, -O-C1-6 alkyl, -S-C1-alkyl 6, -Het5, -CN and -NR31R32； R6 is selected from -H, -OH, -halo, -C 1-6 alkyl, -O-C 1-6 alkyl, -S-C 1-6 alkyl, -NR33R34, and -Het8； R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24,
