Pyrrolo [2,3-b] pyridine-4-yl-amines and pyrrolo [2,3-b] pyrimidine-4-yl-amines as Janus kinase inhibitors

• 收藏
• 分享

专利权人:

INCYTE CORPORATION

发明人:

RODGERS, JAMES D.,WANG, HEISHENG,COMBS, ANDREW P.,SPARKS, RICHARD B.

申请号：

ES05854854

公开号：

ES2536331T3

申请日:

2005.12.21

申请国别(地区):

ES

年份:

2015

代理人:

摘要：

A compound of Formula I-A: ** Formula ** or pharmaceutically acceptable salt thereof, wherein: R1 is H； R2 is H； R3 is H； R4 is methyl； W2 is SO2, CO, COO, C (S) NR12 or CONR12； R7 is halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, cycloalkyl, heteroarylalkyl, heterocycloalkylalkyl, CN, NO2 ORa ", SRa", C (O) Rb ", C (O) NRc" Rd ", C (O) ORa", OC (O) Rb ", OC (O) NRc" Rd, NRc "Rd", NRc "C (O) Rd" , NRc "C (O) ORa", S (O) Rb ", S (O) NRc" Rd ", S (O) 2Rb", S (O) 2NRc "Rd, - (C1-6 alkyl) -CN , - (C1-6 alkyl) -NO2, - (C1-6 alkyl) -ORa ", - (C1-6 alkyl) - SRa", - (C1-6 alkyl) -C (O) Rb ", - ( C1-6 alkyl) -C (O) NRcRd ", - (C1-6 alkyl) -C (O) ORa", - (C1-6 alkyl) -OC (O) Rb "35, - (C1-6 alkyl ) -OC (O) NRc "Rd", - (C1-6 alkyl) -NRc "Rd", - (C1-6 alkyl) -NRc "C (O) Rd", - (C1-6 alkyl) -NRc "C (O) ORa", - (C1-6 alkyl) -S (O) Rb ", - (C1-6 alkyl) -S (O) NRc" Rd ", - (C1-6 alkyl) -S ( O) 2Rb ", or - (C1-6 alkyl) -S (O) 2NRc" Rd "； R12 is H or C1-6 alkyl optionally substituted by 1, 2 or 3 substituents selected from OH, CN, NO2, amino, (C1-4 alkyl) amino, (C2-8 dialkyl) amino, C1-6 haloalkyl, C1-6 acyl, C1-6 acyloxy, C1-6 acylamino, - (C1-6 alkyl) -CN and - (C1-6 alkyl) -NO2； R13 is halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, cycloalkylalkyl, heteroarylalkyl, heterocycloalkylalkyl, CN, NO2, ORa ", SRa", C (O) Rb ", C (O) NRc" Rd ", C (O) ORa", OC (O) Rb ", OC (O) NRc" Rd ", NRc" Rd ", NRc" C (O) Rd ", NRc" C (O) ORa ", S (O) Rb", S (O) NRc "Rd", S (O) 2Rb ", S (O) 2NRc" Rd, (C1-6 alkyl) - CN, - (C1-6 alkyl) -NO2, - (C1-6 alkyl) -ORa ", - (C1-6 alkyl) - SRa", - (C1-6 alkyl) -C (O) Rb ", - (C1-6 alkyl) -C (O) NRc "Rd", - (C1-6 alkyl) -C (O) ORa ", - (C1-6 alkyl) -OC (O) Rb", - (C1 alkyl -6) -OC (O) NRc "Rd", - (C1-6 alkyl) -NRc "Rd", - (C1-6 alkyl) -NRc "C (O) Rd", - (C1-6 alkyl) -NRc "C (O) ORa", - (C1-6 alkyl) -S (O) Rb ", - (C1

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/