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N-hydroxyamidinoheterocycles as modulators of indolamine 2,3-dioxygenase
- 专利权人:
- INCYTE CORPORATION
- 发明人:
- COMBS, ANDREW P.,GLASS, BRIAN M.,SPARKS, RICHARD B.,YUE, EDDY WAI
- 申请号：
- ES07814905
- 公开号：
- ES2444574T3
- 申请日:
- 2007.09.18
- 申请国别(地区):
- ES
- 年份:
- 2014
- 代理人:
- 摘要：
- Compound of Formula III: ** Formula ** or pharmaceutically acceptable salt thereof, wherein: Q is phenyl optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from halo, C1-6 alkyl, C2 alkenyl -6, C2-6 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, CN, NO2, ORa4, SRa4, C (O) Rb4, C (O) NRc4Rd4, C (O) ORa4, OC (O) Rb4, OC (O) NRc4Rd4, NRc4Rd4, NRc4C (O) Rb4, NRc4C (O) NRc4Rd4, NRc4C (O) ORa4, S (O) Rb4, S (O) NRc4Rd4, S (O) 2Rb4, NRc4S (O) 2Rb4 and S (O) 2NRc4Rd4； or Q is C1-6 alkyl substituted by phenyl, wherein said phenyl is substituted by C1-4 alkyl； R2 is halo, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, pentahalosulfanyl, Cy3, CN, NO2, ORa3, SRa3, C (O) Rb3, C (O) NRc3Rd3, C (O) ORa3, OC (O) Rb3, OC (O) NRc3Rd3, NRc3Rd3, NRc3C (O) Rb3, NRc3C (O) NRc3Rd3, NRc3C (O) ORa3, C (>； = NRi3) NRc3Rd3, NRc3C (>； = NRi3) NRc3Rd3, P (Rf3) 2, P (ORe3) 2, P (O) Re3Rf3, P (O) ORe3ORf3, S (O) Rb3, S (O) NRc3Rd3, S ( O) 2R23, NRc3S (O) 2Rb3 or S (O) 2NRc3Rd3； wherein said C1-10 alkyl, C2-10 alkenyl or C2-10 alkynyl is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from halo, C1-10 alkyl, C2-10 alkenyl, C2 alkynyl -10, C1-10 haloalkyl, C1-10 hydroxyalkyl, C1-10 cyanoalkyl, pentahalosulfanyl, Cy3, CN, NO2, ORa3, SRa3, C (O) Rb3, C (O) NRc3Rd3, C (O) ORa3, OC ( O) Rb3, OC (O) NRc3Rd3, NRc3Rd3, NRc3C (O) Rb3, NRc3C (O) NRc3Rd3, NRc3C (O) ORa3, C (>； = NRi3) NRc3Rd3, NRc3C (>； = NRi3) NRc3Rd3, P (Rf3 2, P (ORe3) 2, P (O) Re3Rf3, P (O) ORe3ORf3, S (O) Rb3, S (O) NRc3Rd3, S (O) 2Rb3, NRc3S (O) 2Rb3 and S (O) 2NRc3Rd3； R3 is selected from H, halo, C1-4 alkyl, C2-6 alkenyl and C2-6 alkynyl； R5 is H； Ra3 and Ra4 are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, Cy5 and Cy5- (C1-6 alkyl) -, wherein said C1-6 alkyl , C2-6 alkenyl or C2-6 alkynyl is optionally substituted with 1, 2, 3, 4 or 5 substituents independently sel
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- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
