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4-pyrazolyl-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpyrimidin-2-amines as Janus kinase inhibitors
- 专利权人:
- Incyte Holdings Corporation
- 发明人:
- LI, Yun-long,YAO, Wenqing,RODGERS, James D.
- 申请号：
- ES08848610
- 公开号：
- ES2569528T3
- 申请日:
- 2008.11.13
- 申请国别(地区):
- ES
- 年份:
- 2016
- 代理人:
- 摘要：
- A compound of Formula IIa, IIb, IIc, IId, IIe, IIf or IIg: ** Formula ** or pharmaceutically acceptable salt thereof, wherein: Ring A is aryl or heteroaryl； Q is H, Cy1, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, CN, NO2, ORa1, SRa1, C (O) Rb1, C (O) NRc1Rd1, C ( O) ORa1, OC (O) Rb1, OC (O) NRc1Rd1, NRc1Rd1, NRc1C (O) Rb1, NRc1C (O) NRc1Rd1, NRc1C (O) ORa1, C (>； = NRg) NRc1Rd1, NRc1C (>； = NRg) NRc1Rd1, S (O) Rb1, S (O) NRc1Rd1, S (O) 2Rb1, NRc1S (O) 2Rb1, or S (O) 2NRc1Rd1, wherein said C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl , are optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halosulfanyl, CN, NO2, ORa1, SRa1, C (O) Rb1, C (O) NRc1Rd1, C (O) ORa1, OC (O) Rb1, OC (O) NRc1Rd1, NRc1Rd1, NRc1C (O) Rb1, NRc1C (O) NRc1Rd1, NRc1C (O) ORa1, C (>； = NRg) NRc1Ra1, NRc1C (>； = NRg) NRc1Ra1, S (O) Rb1, S (O) NRc1Rd1, S (O) 2Rb1, NRc1S (O) 2Rb1 and S (O) 2NRc1Rd1； X is halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, CN, NO2, ORa, SRa, C (O) Rb, C (O) NRcRd, C (O) ORa, OC (O) Rb, OC (O) NRcRd, NRcRd, NRcC (O) Rb, NRcC (O) NRcRd, NRcC (O) ORa, C (>； = NRg) NRcRd, NRcC (>； = NRg) NRcRd, S ( O) Rb, S (O) NRcRd, S (O) 2Rb, NRcS (O) 2Rb, or S (O) 2NRcRd, Y is H, Cy2, halo, C1-6 alkyl, C2-6 alkenyl, C2- alkynyl 6, C1-6 haloalkyl, CN, NO2, ORa1, SRa1, C (O) Rb1, C (O) NRc1Rd1, C (O) ORa1, OC (O) Rb1, OC (O) NRc1Rd1, NRc1Rd1, NRc1C (O ) Rb1, NRc1C (O) NRc1Rd1, NRc1C (O) ORa1, C (>； = NRg) NRc1Rd1, NRc1C (>； = NRg) NRc1Rd1, S (O) Rb1, S (O) NRc1Rd1, S (O) 2Rb1, NRc1S (O) 2Rb1, or S (O) 2NRc1Rd1, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl or C1-6 haloalkyl are optionally substituted with 1, 2, 3, 4 or 5 independently selected substituents halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halosulfanyl, CN, NO2, ORa1, SRa1, C (O) Rb1, C (O) NRc1Rd1, C (O) ORa1 , OC (O) Rb1, OC (O) NRc1Rd1, NRc1Rd1, NRc1C (O) Rb1, NRc1C
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
