The present invention discloses and claims a series of substituted N-heteroaryl tetrahydro-isoquinoline derivatives of formula (I).Wherein R, R1, R2, X, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this invention also discloses methods of preparation of substituted N-heteroaryl tetrahydro-isoquinoline derivatives of formula (I) and intermediates therefor.本發明揭示及主張一系列式(I)經取代N-雜芳基四氫異喹啉衍生物並申請其專利權。其中R、R1、R2、X、m、n和p如本文所定義。更具體地說，本發明之化合物是H3受體調節劑，因此可作為藥劑使用，尤其有助於治療和/或預防H3受體調控的各種疾病，包括與中樞神經系統相關的疾病。此外，本發明還揭示式(I)的取代的N-雜芳基四氫異喹啉衍生物及其中間體的製備方法。
