The present invention relates to substituted imidazo[4,5-c]quinoline derivatives of formula (I), wherein R1, R2and R3are as defined in the specification, processes for their preparation, pharmaceutical compositions comprising compounds of the present invention and their use in the treatment of diseases or disorders mediated by one or more kinases, particularly proliferative diseases or disorders such as cancer. These compounds can also be used in the treatment of inflammation and angiogenesis related disorders.本發明有關於式(I)的取代咪唑並[4,5-c]喹啉衍生物、製備它們的製程、包含本發明化合物的醫藥組成物以及它們在治療由一或更多個激酶所媒介的疾病或失調的用途，特別是例如癌症的增生性疾病或失調，其中R1、R2以及R3係如同說明書中所定義。這些化合物也可用於治療發炎以及與血管新生相關的失調。
