經取代之吡啶及其使用方法农业专利-农业学术服务平台

发明人:: ALTENBACH, ROBERT J.,欧登巴克　罗伯Ｊ,歐登巴克　羅伯Ｊ,COWART, MARLON D.,科瓦特　玛利昂Ｄ,科瓦特　瑪利昂Ｄ,DE MUNCK, TOM ROGER LISETTE,迪　孟克　汤姆　罗杰　李赛特,迪　孟克　湯姆　羅傑　李賽特,德哈西　蒙托维特　赛巴斯汀　尚　杰克斯　希利可,德哈西　蒙托維特　賽巴斯汀　尚　傑克斯　希利可,GFESSER, GREGORY A.,欧登巴克罗伯J,歐登巴克羅伯J,科瓦特玛利昂D,科瓦特瑪利昂D,迪孟克汤姆罗杰李赛特,迪孟克湯姆羅傑李賽特,德哈西蒙托维特赛巴斯汀尚杰克斯希利可,德哈西蒙托維特賽巴斯汀尚傑克斯希利可

摘要：: The invention discloses compounds of Formula I wherein X, R1, R2, and R3 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.本發明揭示式I化合物，其中X、R1、R2及R3係如本文中所定義。本發明係關於化合物及其用於治療囊性纖維化之用途、其產生方法、包括其之醫藥組合物及藉由投與本發明化合物來治療囊性纖維化之方法。