作為免疫調節劑之氘化化合物农业专利-农业学术服务平台

发明人:: FAN, PINGCHEN,樊　平臣,LUI, REBECCA M.,雷　敏瑜,MALI, VENKAT REDDY,马利　帆克　罗迪,馬利　帆克　羅迪,SINGH, RAJINDER,斯颖　罗瑾德,斯穎　羅瑾德,ZENG, YIBIN,曾一斌,ZHANG, PENGLIE,张　朋烈,張　朋烈

摘要：: Compounds are provided to modulate the C5a receptor. The compounds have the following Formula (I):including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2and R3are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.本發明提供可調節C5a受體之化合物。該等化合物具有下式(I)：包括其立體異構體及醫藥上可接受之鹽，其中R1、R2及R3係如文中所定義。亦揭示與該等化合物之製備及使用有關的方法、以及包含該等化合物之醫藥組合物。