The present invention provides Formula (1A) compoundsthat act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokinase. X, Y, Z, R1, R2, R3, and R4are as described herein.本發明提供式(1A)化合物其係用作為葡糖激酶活化劑;其藥學組成物;及治療由葡糖激酶所媒介之疾病、病症或病情之方法。X、Y、Z、R1、R2、R3及R4係如此處所述。