A compound of Formula (I) or its pharmaceutically acceptable salt or hydrate, ** Formula ** wherein one of A and B represents CO, and the other of A and B represents CO or CH2； D represents S； R1 represents H, or one or two equal or different cases of F, Br, C1-4 alkylhydrocarbyl, OH, O-C1-4 alkylhydrocarbyl, NO2, NHC (O) -C14 alkylhydrocarbyl, NH2, NH (C1-4 alkylhydrocarbyl) or N (C14 alkyl hydrocarbyl) 2； R2 in each case represents F, CF3, H or C14 alkylhydrocarbyl； R3 in each case represents F, Cl, OH, CH (OH) -C14 alkyl hydrocarbyl, O-C1-4 alkylhydrocarbyl, NHC (O) - C1-4 alkylhydrocarbyl, NH2, NH (C1-4 alkylhydrocarbyl), N (C1 alkyl hydrocarbyl -4) 2, C (O) O-C14 alkyl hydrocarbyl, C (O) NH2, C (O) NH (C1-4 alkyl hydrocarbyl), C (O) N (C14 alkyl hydrocarbyl) 2, C (O) NHOH, C (O) NH (O-C1-4 alkylhydrocarbyl), C (O) -C1-4 alkylhydrocarbyl, S (O) -C1-4 alkylhydrocarbyl, SO2-C14 alkylhydrocarbyl, SO2NH-C1-4 alkylhydrocarbyl, NHSO2 C1-4 alkylhydrocarbyl, O2C-C1-4 alkylhydrocarbyl, NHC (O) -C14 alkylhydrocarbyl, CN, CH>； = NOH, CH>； = N (O-C1-4 alkylhydrocarbyl), C (C14 alkylhydrocarbyl)>； = NOH, C (C1-4 alkylhydrocarbyl )>； = N (O-C14 alkylhydrocarbyl), CH>； = NCN, CH>； = NC (O) -C1-4 alkylhydrocarbyl, CH>； = C (CN) 2, CH>； = CHNO2, C (>； = NH) NH (C1-4 alkyl hydrocarbyl), C (C14 alkyl hydrocarbyl)>； = NCN, C (C1-4 alkyl hydrocarbyl)>； = NC (O) - C14 alkylhydrocarbyl>； C (C1-4 alkyl hydrocarbyl)>； = C (CN) 2 or C ( C14 alkylhydrocarbyl)>； = CHNO2； R4 represents H, C1-8 alkylhydrocarbyl or (CH2) nAr-R5； R5 represents H, 1 to 4 F the same or different, CF3, CN, Cl, C14 alkyl hydrocarbyl, OH, O-C 1-4 alkylhydrocarbyl, NHC (O) -C14 alkyl hydrocarbyl, NH2, NH (C 1-4 alkylhydrocarbyl), N ( C14 alkyl hydrocarbyl 2, C (O) O-C 1-4 alkyl hydrocarbyl, OOC C 14 alkyl hydrocarbyl, C (O) NH 2, C (O) NH (C 1-4 alkyl hydrocarbyl), C (O) N (C 14 alkyl hydrocarbyl) 2, C (O) - C1-4 alkylhydrocarbyl, S (O) C1-4 alkylhydrocarbyl, SO2-C1-4 alkylhydrocarbyl, O2
