A compound of Formula (I) or Formula (II), a pharmaceutically acceptable salt, or a hydrate thereof, wherein A, B and E independently represent CH2, or CO； D represents S, NH, or NC1-6alkylhydrocarbyl； R represents H or R3； R1 represents H, or one or two same or different occurrences of F, Cl, Br, C1-4alkylhydrocarbyl, OH, OC1-4alkylhydrocarbyl, NO2, NHC (O) C1-4alkylhydrocarbyl, NH2, NH (C1-4alkylhydrocarbyl), or N (C1-4alkylhydrocarbyl) 2； R2 at each occurrence represents F, CF3, H or C1-4alkylhydrocarbyl； R3 at each occurrence represents (CH2) mR4 and m represents an integer from 1 to 6； R4 represents F, Cl, H, C1-4alkylhydrocarbyl, OH, OC1-4alkylhydrocarbyl, NHC (O) C1-4alkylhydrocarbyl, NH2, NH (C1-4alkylhydrocarbyl), N (C1-4alkylhydrocarbyl) 2, or O2CR5； R5 represents CHR6NR7R8, CHR6NR9C (O) CHR10NR7R8, heterocycle W, or CHR6NR9C (O) W； R6, R9 and R10 20 independently represent H or C1-4alkylhydrocarbyl； R7 and R8 independently represent H, C1-4alkylhydrocarbyl, or taken together in combination represent 1,3-propylidene, 1,4-butylene, 1,5-pentylene, 1,6-hexylidene, and W represents a saturated or unsaturated heterocycle of four to eight members.Un compuesto de la Fórmula (I) o de la Fórmula (II), una sal farmacéuticamente aceptable, o un hidrato del mismo, en donde A, B y E representan independientemente CH2, o CO； D representa S, NH, o NC1-6alquilhidrocarbilo； R representa H o R3； R1 representa H, o una o dos apariciones iguales o diferentes de F, Cl, Br, C1-4alquilhidrocarbilo, OH, OC1- 4alquilhidrocarbilo, NO2, NHC(O)C1-4alquilhidrocarbilo, NH2, NH(C1-4alquilhidrocarbilo), o N(C1- 4alquilhidrocarbilo)2； R2 en cada aparición representa F, CF3, H o C1-4alquilhidrocarbilo； R3 en cada aparición representa (CH2)mR4 y m representa un número entero de 1 a 6； R4 representa F, Cl, H, C1-4alquilhidrocarbilo, OH, OC1-4alquilhidrocarbilo, NHC(O)C1-4alquilhidrocarbilo, NH2, NH(C1-4alquilhidrocarbilo), N(C1-4alquilhidrocarbilo)2, o O2CR5； R5 representa CHR6NR7R8, CHR6NR9
