BECKMANN, CHRISTOPH H.,MOSS, STEVEN JAMES,SHERIDAN, ROSE MARY,ZHANG, MINGQIANG,WILKINSON, BARRIE
申请号：
ES06710063
公开号：
ES2527530T3
申请日:
2006.03.10
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound according to the following Formula (I): ** Formula ** in which: X represents a bond or CH2； R1 represents a keto group or (H, H)； R2 represents OH or OMe； R3 represents H, OH or OMe； R4 and R5 each independently represents H or OH； R6 represents -R7, -C (O) R7, - (CH2) 2-O- [CR21R22-O] to-C (O) -R23； -CR21R22-O-C (O) -R23； -POR19R20, -PO (OR19) (OR20) or Y-R15； R7 represents - (CR8R9) m (CR10R11) pCR12R13R14； R8 and R9 each independently represent C1-C4 alkyl, C2-C4 alkenyl or C2-C4 alkynyl, any of these groups being optionally substituted with -PO (OH) 2, -CF2PO (OH) 2, -OH, -COOH or -NH2； or R8 and R9 each independently represent H, trifluoromethyl or F； R10, R11, R12, R13 and R14 each independently represents C1-C4 alkyl, C2-C4 alkenyl or C2-C4 alkynyl, any of these groups being optionally substituted with -PO (OH) 2, -CF2PO (OH) 2 , -OH, -COOH or -NH2； or R10, R11, R12, R13 and R14 can be independently selected from H, - (CR8R9) qNH2, - (CR8R9) qOH, CF3, F, COOH； or R10 and R11 or R12 and R13 or R13 and R14 can be taken together with the carbon to which they are attached to form a C3-C6 cycloalkyl or a 3- to 6-membered heteroalkyl ring containing one or more heteroatoms selected from N, O and S and which is optionally substituted with up to 5 groups - (CR8R9) qOH, - (CR8R9) qNH2 or COOH； Y>； = bond, -C (O) -O-, - (CH2) 2-O-C (O) -O-； R15 represents ** Formula ** R16 are each independently H or OH； R17 is independently selected from H, OH and NH2； R18 is independently selected from H, -CH3, -CH2OH and -COOH； with the proviso, however, that no more than 2 groups selected from R16, R17 and R18 represent H or CH3； R19 and R20 each independently represents H or C1-C4 alkyl, or R19 and R20 together represent>； = CH2； R21 is independently selected from H, CH3； R22 is independently selected from H, -CH3, -CH>； = CH2, -CH2Cl, -CHCl2, -CCl3, -CH (OH) Me, -CH2OH, -CH2CH3, -CH (CI) Me.Un compuesto según la Formula (I) siguiente:**Fórmula** en la que: X repr
