APPLICATION OF AMITRIPTILINE FOR BLOCKING OF BRAIN HEMICANALS AND METHOD OF POTENTIATION OF ITS INFLUENCE IN VIVO

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专利权人:

ТЕРАНЕКСЮ (FR)

发明人:

ЖАНСОН Тиффани (FR),ШАРВЕРИА Матьё (FR),МУТОН Франк (FR)

申请号：

RU2018102640

公开号：

RU2018102640A

申请日:

2016.07.15

申请国别(地区):

RU

年份:

2019

代理人:

摘要：

The present invention relates to the use of amitriptyline as an inhibitor of connexin hemichannels (HC) in the Central Nervous System (CNS). This HC-blocking agent is advantageously used to treat disorders involving misregulated HC (notably neuropathic pain, neurodegenerative disorders, ischemic brain injury and inflammatory intestinal conditions). Additionally, the invention provides a method to enhance the therapeutic effect of amitriptyline for its common indications. The method of the invention involves combining amitriptyline with another HC-blocking agent, mefloquine.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/