USE OF AMITRIPTYLINE FOR BLOCKING BRAIN HEMICHANNELS AND METHOD FOR POTENTIATING ITS EFFECT IN VIVO

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专利权人:

发明人:

JEANSON TIFFANY,CHARVERIAT MATHIEU,MOUTHON FRANCK

申请号：

IN201817000356

公开号：

IN201817000356A

申请日:

2018.01.03

申请国别(地区):

IN

年份:

2018

代理人:

摘要：

The present invention relates to the use of amitriptyline as an inhibitor of connexin hemichannels (HC) in the Central Nervous System (CNS). This HC blocking agent is advantageously used to treat disorders involving misregulated HC (notably neuropathic pain neurodegenerative disorders ischemic brain injury and inflammatory intestinal conditions). Additionally the invention provides a method to enhance the therapeutic effect of amitriptyline for its common indications. The method of the invention involves combining amitriptyline with another HC blocking agent mefloquine.

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中国工程科技知识中心

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http://www.ckcest.cn/home/