Use of amitriptyline for blocking brain hemichannels and method for potentiating its effect in vivo

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专利权人:

Theranexus

发明人:

Jeanson, Tiffany,Charveriat, Mathieu,Mouthon, Franck

申请号：

AU2016293117

公开号：

AU2016293117A1

申请日:

2016.07.15

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

The present invention relates to the use of amitriptyline as an inhibitor of connexin hemichannels (HC) in the Central Nervous System (CNS). This HC-blocking agent is advantageously used to treat disorders involving misregulated HC (notably neuropathic pain, neurodegenerative disorders, ischemic brain injury and inflammatory intestinal conditions). Additionally, the invention provides a method to enhance the therapeutic effect of amitriptyline for its common indications. The method of the invention involves combining amitriptyline with another HC-blocking agent, mefloquine.

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中国工程科技知识中心

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