Stacey Melquist,Steven Kanner,David B. Rozema,David L. Lewis,Lauren J. Almeida,Darren H. Wakefield,Vladimir S. Trubetskoy,Tao Pei,Zhen Li,Aaron Almeida
申请号：
US15281309
公开号：
US09932586B2
申请日:
2016.09.30
申请国别(地区):
US
年份:
2018
代理人:
摘要：
RNA interference (RNAi) agents and RNAi agent conjugates for inhibiting the expression of the LPA (apo(a)) gene are described. Pharmaceutical compositions comprising one or more LPA RNAi agents optionally with one or more additional therapeutics are also described. Delivery of the described LPA RNAi agents to liver cells in vivo provides for inhibition of LPA gene expression and treatment of cardiovascular and cardiovascular-related diseases.
