КЭТИБА Джордж Эдвин (US),КАНН Дэвид (US),СУНГ Леонард (US),ГОТЬЕ Келси (US),ГЛИКМАН Лаура Хикс (US),ЛЕОНГ Джастин (US),МАКУЭРТЕР Сара М. (US),ДУБЕНСКИ Томас У. Мл. (US),МакКЕННА Джеффри (US),КЭНХАМ Ст
申请号：
RU2018119306
公开号：
RU2018119306A
申请日:
2016.10.28
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are 2′- or 3′-mono-fluoro substituted, or 2′3′-di-fluoro substituted mixed linkage 2′,5′-3′,5′ CDNs.
