SMITH, MARK,BAKER, JAMES,SCHUMACHER, FELIX,CADDICK, STEPHEN,CHUDASAMA, VIJAY,MARUANI, ANTOINE
申请号：
CA2866699
公开号：
CA2866699A1
申请日:
2013.03.08
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention relates to antibodies and antibody fragments, one or more of whose native inter-chain disulfide bridges have been replaced with a specific bridging moiety. The bridging moiety can be selectively targeted to inter-chain disulfide bonds within the antibody or antibody fragment, enabling the construction of more homogeneously modified products such as antibody-drug conjugates.
