Mark Smith,James Baker,Felix Schumacher,Stephen Caddick,Vijay Chudasama,Antoine Maruani
申请号：
US14383260
公开号：
US20150031861A1
申请日:
2013.03.08
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to antibodies and antibody fragments, one or more of whose native inter-chain disulfide bridges have been replaced with a specific bridging moiety. The bridging moiety can be selectively targeted to inter-chain disulfide bonds within the antibody or antibody fragment, enabling the construction of more homogenously modified products such as antibody-drug conjugates.
