FIONA CHAN,DEREK EDWARD JOHN,SIMON D. EDWARDS,LINDSAY BROWN,BASIL HARTZOULAKIS,DAVID MADGE,RICHARD BLUNT
申请号：
ARP120104296
公开号：
AR090037A1
申请日:
2012.11.14
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Claim 1: a compound characterized by formula (1) or a pharmaceutically acceptable derivative, characterized by: A is or s； X is n or Cr * II； V is n or Cr * III； Z is n or Cr * IV； wherein 1 or 2 is V, X and Z are n； R1 is selected from the optional alternative asphalt and optionally replaces cycloarmour. R2 was selected from h, halo, - CN, trifluometyl, alternative, alcox alternative, - nr8308； - r83099；-No. 8310； (c) r8311；-No. 8310； (s (o) 8322； r831181；-S (o) 8322； - 8308； - r83099；-CONR⁴R⁵,-CO₂R⁷,Substituted oxazolinilo, - sr8308；-S (O) R y -S (O) RR3: I from h, halo CN, trifluometilo, optional replacement asphalt, optional replacement alcox, optional replacement heterocyclic hyperoxia, - No. 8310；； C (o) r8311；-No. 8310； (s (o) 8322； r831181；-S (o) 8322； - 8308； - r83099；-CONR⁴R⁵,-CO₂R⁷,-8312； 8313；-C ° C-J, optionally substituted cycloalkyl-J and - (NRᵃRᵇ) -J； each of R³II, R³III, and R³IV is independently selected from H, halo, -CN, trifluoromethyl, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted heterocycloalkoxy, optionally substituted heterocycloalkylalkyl, -NR⁶C (O) R⁷,-No. 8310； (s (o) 8322； r831181；-S (o) 8322； - 8308； - r83099；-CONR⁴R⁵,-Lessor - conr8308； - No. 83099 optional replacement, - No. co8322； - No. 831181；-No. 830404； R1,-C CJ cicloalquil-J opcionalmente sustituido y - (NR R) -J con la condici n de que R es -C CJ cicloalquil-J opcionalmente sustituido o - (NR R) -J y 2Fo al menos uno de R II R III - that is...That's it, that's it.wherein the optionally substituted heterocycloalkyl ring that optionally forms a bridge is selected from the group consisting of azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl, tetrahydro-1,3-oxazinyl, hexahydropyrimidinyl, 1,4-thiazanyl, azepanyl, 1,4-oxaazepanyl , and 1,4-tieazepanyl； where Rᶜ and Rᵈ join to form an optionally substituted 4- and 7-membered heterocycloalkyl ring, which is optionally linked to form a bridge, optionally substituted C₁₋₂ alkylene, -NR⁶-,- that i
