MICHAEL E. KORT,LAURENT MOUNIER,OLIVIA POUPARDIN,JEROME AMAUDRUT,MARTINE BARTH,DOMINIQUE POTIN,ADRIAN C. HOBSON,KEVIN P. CUSACK,ERIC C. BREINLINGER,MARIA A. ARGIRIADI
申请号：
ARP160101700
公开号：
AR104934A1
申请日:
2016.06.08
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
This application is for the same medicament acceptable compounds and salts used for the treatment of immune disorders. 1. Requirement 1: a compound (1) with formula characteristics,1. Acceptable salt or its stereoisomer, W is C or cr74919；L¹ is connected to W or Y； and A and E are independently C or N with the proviso that they are not both N； V is CR³ or N； X is CRᵃ,No. 7491,N. O, this is C, cr74919,No. 7491,n. Or s； Z is Cr * 3 or N； or W is n or NR 7491；L¹ is connected to W or Y； and A and E are independently C or N with the proviso that they are not both N； V is CR³ or N； X is CRᵃ,No. 7491,This is C, cr74919,O n； Z is Cr * m or N； or CY is an aromatic ring, heteroaromatic or partially saturated, composed of six members, replaced by R1 and R2；L es -CH (R) --C (R) (R) --C (O) - o -N (R) -L es -C (O) -- that is...-C (R) (R) -- yes.-S (O) --S (O) -R¹ and R² are independently halo, -O-C₁₋₃ alkyl, -O-C₃₋₆ cycloalkyl, optionally substituted C₃₋₆ cycloalkyl, or -C₁₋₃ alkyl； each R³ is independently H, CF₃,CN, halo, -C (= O) C₁₋₃ alkyl, -C (O) N (Rᵉ) ₂,-No. 749784；-OCHF₂,OCF83223,-O-C₁₋₃ alkyl, -O-C₃₋₆ cycloalkyl, -S-C₁₋₃ alkyl, C₁₋₆ optionally substituted alkyl, C₃₋₆ optionally substituted cycloalkyl, optionally substituted heteroaryl or optionally substituted heterocycle； R⁴ is H, -OH, C₁₋₆ optionally substituted alkyl, -NR⁵R⁶,C₃₋₆ optionally substituted cycloalkyl or - (CH₂) ₘ-optionally substituted heterocycle； where R⁵ is H or -C₁₋₃ alkyl, and R⁶ is C₁₋₄ optionally substituted alkyl, C₃₋₆ optionally substituted cycloalkyl or - (CH₂) ₘ -substituted heterocycle； or R⁵ and R⁶,With the addition of nitrogen atoms, they form an optional heteromorphic period, each r74919 is an independent H - (c) (o) ch832323；C₁₋₆ optionally substituted alkyl, C₃₋₆ optionally substituted cycloalkyl or -S (O) ₂-phenyl； each Rᵇ is independently H, F, OH, -O-C₁₋₃ alkyl, or C₁₋₃ alkyl； Rᶜ is independently H or -C₁₋₃ alkyl； each Rᵈ is independently H, F, or C₁₋₃ alkyl； or Rᵈ and Rᵇ form a C₃₋₅
