GAINES SIMON,게인즈, 시몬,HOLMES IAN PETER,홈즈, 이안, 피터,MARTIN STEPHEN LEWIS,마틴, 스티븐, 루이스,WATSON STEPHEN PAUL,왓슨, 스티븐, 폴
申请号：
KR1020137014317
公开号：
KR1020130079628A
申请日:
2004.09.10
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
Compounds of Formula (I): Wherein: A represents bond, C 1-6 alkyl or CH=CH-C 1-4 alkyl B represents bond, O, S, SO, SO 2 , CO, CR 7 R 8 , CO 2 R 14 , CONR 14 R 15 , N(COR 14 )(COR 15 ), N(SO 2 R 14 )(COR 15 ) or NR 14 R 15 D represents bond, or C 1-6 alkyl E represents substituted aryl or substituted or unsubstituted heteroaryl Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring X represents O, S, SO, SO 2 , CO, CNR 5 , CNOR 5 , CNNR 5 R 6 , NR 11 or CR 7 R 8 Y represents CR 5 OR 11 , CR 5 SR 11 , NOR 5 , CR 5 NR 6 R 11 , SO, SO 2 , CO, CNR 5 , CNOR 5 or CS R 1 and R 1 each independently represents H, C 1-6 alkyl or C 1-4 alkylaryl R 2 represents CO 2 R 12 , CH 2 OR 12 or CONR 12 R 13 , CONR 12 OR 13 , NR 12 COR 13 , SR 12 , PO(OH) 2 , PONHR 12 or SONHR 12 R 3 represents H, C 1-6 alkyl or C 1-4 alkylaryl R 4 represents optionally substituted aryl or heteroaryl Z represents a bond, CH 2 , O, S, SO, SO 2 , NR 5 , OCR 5 R 6 , CR 9 R 10 O or Z, R 4 and Q together form an optionally substituted fused tricyclic group R 5 and R 6 each independently represent H, C 1-6 alkyl or C 1-4 alkylaryl R 7 and R 8 each independently represent H, halo, C 1-6 alkyl or C 1-4 alkylaryl R 9 and R 10 each independently represents H, C 1-6 alkyl optionally substituted by halo, cyano, OR 11 or NR 6 R 11 , C 1-4 alkylaryl optionally substituted by halo, cyano, OR11 or NR 6 R 11 , OR 11 or, together with the N to which they are attached, R 9 and R 10 form a heterocyclic group: R 11 represents H, C 1-6 alkyl, C 1-4 alkylaryl or COR 5 R 12 and R 13 each independently represent H, C 1-3 alkyl, C 1-3 alkylaryl or C 1-3 alkylheteroaryl or, together with the functionality to which they are attached, R 12 and R 13 form a heterocyclic group: R 14 and R 15 each independently represent H, C 1-6 alkyl, C 1-4 alkylaryl or C 1-4 alkylheteroaryl or together with the functionality to which they are attached R 14 and R 15 form a het
