Claim 1: a compound having the formula (1),Or pharmaceutically acceptable salts thereof； where W is a compound of formula (2)； a u00b9 and a u2074 c or n are independent； each is A u00b3 a-squared and COr one of A u00b3 a-squared and when n is r u2076 and r u2077 form a Ring； b and C are independently a ring carboc u00edclico optionally substituted aryl, 5 to 7 members,Heteroaryl or Heterocyclic Ring containing n, o or s； z u00b9, z u00b2 and are independently nr u00b9 u00b9% Cr, c = o, - or, or u2081 u208b u2082 (cr u2082) = C - r u00b9 u00b2； r u00b9 are independently and R u00b2 Halo, or u00b9 u00b2, NR (r u00b9 u00b2), sr u00b9 u00b2,Or rent a c u2081 u208b u2086, alquenilo c u2082 u208b u2086 alquinilo c u2082 u208b u2086 or optionally substituted； or one of r u00b9 and R u00b2 is h； r u00b3 is u2080 u208b u2082so u2082r u00b9 u00b2 (cr u2082), (cr u2082) u2080 u208b u2082so u2082nrr u00b9 u00b2 (cr u2082) u2080 u208b u2082co u2081 u208b u2082r u00b9 u00b2 (cr u2082) u2080 u208b u2082conrr u00b9 u00b2 r u2074 r u2076, cyano, or；R u2077 and r u00b9 u2070 are independently an alkyl c u2081 u208b u2086, alquenilo c u2082 u208b u2086 alquinilo c u2082 u208b u2086 or optionally substituted； or u00b9 u00b2, NR (r u00b9 u00b2), Halo, Nitro, so u2082r u00b9 u00b2 (cr u00b2 u209ar u00b9 u00b3 or X r u2074)； or,R u2077 and r u00b9 u2070 are independently h, r, r u2075 and r u2075 'are independently H or alkyl c u2081 u208b u2086； r u2078 and r u2079 are independently alkyl c u2081 u208b u2086, alquenilo c u2082 u208b u2086 alquinilo c u2082 u208b u2086, Halo, or XOr one of r u2078 and r u2079 is H when r u00b9 and R u00b2 form a Ring； and under the condition that one of r u2078 and r u2079 is X； Alternatively, r u00b9 and R u00b2, or r u2076 and r u2077, r u2077 and r u2078, or r u2079 and r u00b9 u2070,When bound to a carbon Atom can form a ring carboc u00edclico FUSED monocyclic or optionally substituted aryl 5 to 7 members,Or heteroaryl Ring or Heterocyclic comp
