EDDY JEAN EDGARD FREYNE MARC WILLEMS WERNER CONSTANT JOHAN EMBRECHTS
申请号：
IN4293/DELNP/2007
公开号：
IN274012B
申请日:
2007.06.06
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z and Z represent NH Y represents -C3-9alkyl-, -C3-9alkenyl-C1-5alkyl-NR6-C1-5 alkyl-,C1-5 alkyI-NR7-CO-C1-5 alkyl-, -C1-6alkyl-CO-NH-, -C1-6 alkyl-NH-CO-,R4 Z2 6 NR2 -C1-2alkyl-CO-Het-CO-, -C1-3alkyl-NH-CO--C1-2alkyl-NII-CO-L1 -NII-, -NII-CO-L2- -C1-2alkyl-CO-NlI-L3-CO-,-C1-2lkyl-NH-CO-l31NH-CO-C1-3alkyl-, -C1-2alkyl-CO-NH-L3-CO-NH-C1-3a1ky]-, -C1-3alkyl-NR11-CH2-CO-NH-C1-3alkyl-, Hct5-CO-C1-2alkyl , -C1-5 alkyl-CO-NH-C1-3alkyl-CO-NH-, -C1-5alkyl-NR13-CO-C1-3alkyl-NH-, -C1-3alkyl-NH-CO-Hct27-CO-, or -C1-3alkyl-CO-Hct28-CO-NH- X1 represents a direct bond, O, -O-C1-2alkyl-, -CO-C1-2alkyl-, -NRl6-C1-2alkyl-, -CO-NR17-, Het23-C1-2alkyl- or C1-2alkyl X2 represents a direct bond, O, -O-C1-2alkyl-, -CO-C1-2alkyl-, -NR18-C1-2alkyl-, -CO-NR19-, Het -C1-2alkyl- or C1-2alkyl R1 and R5 each independently represent hydrogen, halo, C1-6alkyloxy- or C1-6alkyloxy- substituted with Het1 or C1-4alkyloxy- R2 and R4 each independently represent hydrogen or halo R represents hydrogen or cyano: R6 , R7 , R13 , R17 and R19 represent hydrogen R11 represents hydrogen or C1-4 alkyl R16 and R18 represent hydrogen, C=alkyl or Het17 -C1-4alkyl- L , L and L each independently represents C1-4alkyl optionally substituted with one or where possible two or more substituents selected from phenyl, methylsulfide, cyano, polyhaloC1-4alkyl phenyl , C1-4 alkyloxy, pyridinyl, mono- or di(C1-4alkyl)3-amino-or C3-6cycloalkyl Het1 , Het2 , Het17 each independently represent morpholinyl, oxazolyl, isoxazolyl, or piperazinyl Het3 , Het4 , Het5 each independently represent morpholinyl, piperazinyl, piperidinyl or pyrrolidinyl Het10 represents piperazinyl, piperidinyl, pyrrolidinyl or azetidinyl Het2223 represents morpholinyl, oxazolyl, isoxazolyl or piperazinyl wherein said Het22 is optionally substituted with C1-4alkyl Het and He
