TRAM. N. HUYNH,HAROLD MASTALERZ,GUIFEN ZHANG,ASHOK VINAYAK PURANDARE,KURT ZIMMERMAN,YUFEN ZHAO,WALTER LEWIS JOHNSON,AMY C. HART,LIQI HE,WAYNE VACCARO,CHRISTINE M. TARBY,BRIAN E. FINK,YONG ZHANG,LIBING
申请号：
ARP130102495
公开号：
AR092349A1
申请日:
2013.07.12
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
These zinc acyl dicarboxylates inhibit the activity of quinase protein and make it an antineoplastic agent. 1. Claim 1: a compound characterized by formula (1),or a pharmaceutically acceptable salt thereof, wherein R¹ is selected from the group consisting of H, F, Cl, Br, CN and C₁₋₆ alkyl；RZ was selected from a group consisting of arilo replaced by 1-5r8310 and arilo replaced by 1-5r8310；R³ is selected from the group consisting of hydrogen and C₁₋₆ alkyl substituted with 1-5 Rᵉ；Optional clause, R2 and R3,They combine with nitrogen atoms to form a heterocycle replaced by 1-5r8310.R⁴ is selected from the group consisting of H, C₁₋₆ alkyl substituted with 1-5 Rᵉ,- (CH) OR- (CH) S (O) R- (CH) C (3DO) R- (CH) NR R- (CH) C (3DO) NR R- (CH) NR C (3DO) R- (CH) NR C (3DO) OR- (CH) OC (3DO) NR R- (CH) NR C (3DO) NR R- (CH) C (3DO) OR- (CH) S (O) NR R- (CH) NR S (O) NR R- (CH) NR S (O) R- (CH₂) ʳ-carbocyclyl C₃₋₁₀ substituted with 1-5 Rᵉ,(ch832227) 691 - substituting 1-5 r74977 for non propylene；R⁵ is selected from the group consisting of H and C₁₋₆ alkyl substituted with 1-5 Rᵉ；R8310,In each case, it is selected independently of the categories of H, F, Cl, Br, CN - (CR 7501； (r7501) 691； (r8311)；No.8322；-Or 74955,-C (3DO) NR R-C (3DO) R-No. 7491； (= O) or7495；-No. 7491； (= O) (CR 7501；) No. 75011；； No. 7491； - r74919；Replace c833218331-8326 with 1-5 r74977；a. Alquenilo c83322831i8324 replaced with 1-5 r74977；- (CRᵍRᵍ) ʳ-C carbo carbocycle substituted with 1-5 R⁸ and - (CRᵍRᵍ) ʳ-heterocyclyl substituted with 1-5 R⁸；O two adjacent r83100s groups form an isomerized heterocycle or thyroid with the ring atoms connected to them, each group is replaced by 1-5 r831222；R8311th,in each case, it is independently selected from the group consisting of H, C₁₋₆ alkyl substituted with 1-5 Rᵉ,- (CH₂) ʳ-C-carbocyclyl substituted with 1-5 R⁸ and - (CH₂) ʳ-heterocyclyl substituted with 1-5 R⁸；O r8311 and r8311；They are linked with nitrogen atoms to form a heterocycle replaced by 1-5r831222.R832
