CHEN, XIAOCHENG,DENNIS, MARK S.,KANE, LESLEY ANN,KIM, DO JIN,LEWCOCK, JOSEPH W.,PODA, SURESH,RAKHIT, RISHI,SHUKLA, RINKAN,SILVERMAN, ADAM P.
申请号：
CA3053379
公开号：
CA3053379A1
申请日:
2018.02.15
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
In one aspect, antibodies that specifically bind to a human Tau protein are provided. In some embodiments, an anti-Tau antibody recognizes an epitope within residues 111-125 of full-length human Tau, an epitope within residues 251-270 and/or residues 346-360 of full-length human Tau, or an epitope within residues 186-205 of full-length human Tau. In some embodiments, an anti-Tau antibody specifically binds to phosphorylated human Tau, unphosphorylated human Tau, and/or multiple splice isoforms of human Tau. An anti-Tau antibody disclosed herein may also include one or two modified Fc polypeptides.
