Xiaocheng Chen,Mark S. Dennis,Lesley Ann Kane,Do Jin Kim,Joseph W. Lewcock,Suresh Poda,Rishi Rakhit,Rinkan Shukla,Adam P. Silverman
申请号：
US16543367
公开号：
US20200216522A1
申请日:
2019.08.16
申请国别(地区):
US
年份:
2020
代理人:
摘要：
In one aspect, antibodies that specifically bind to a human Tau protein are provided. In some embodiments, an anti-Tau antibody recognizes an epitope within residues 111-125 of full-length human Tau, an epitope within residues 251-270 and/or residues 346-360 of full-length human Tau, or an epitope within residues 186-205 of full-length human Tau. In some embodiments, an anti-Tau antibody specifically binds to phosphorylated human Tau, unphosphorylated human Tau, and/or multiple splice isoforms of human Tau. An anti-Tau antibody disclosed herein may also include one or two modified Fc polypeptides.
