Chen, Xiaocheng,Dennis, Mark S.,Kane, Lesley Ann,Kim, Do Jin,Lewcock, Joseph W.,Poda, Suresh,Rakhit, Rishi,Shukla, Rinkan,Silverman, Adam P.
申请号：
AU2018221049
公开号：
AU2018221049A1
申请日:
2018.02.15
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
In one aspect, antibodies that specifically bind to a human Tau protein are provided. In some embodiments, an anti-Tau antibody recognizes an epitope within residues 111-125 of full-length human Tau, an epitope within residues 251-270 and/or residues 346-360 of full-length human Tau, or an epitope within residues 186-205 of full-length human Tau. In some embodiments, an anti-Tau antibody specifically binds to phosphorylated human Tau, unphosphorylated human Tau, and/or multiple splice isoforms of human Tau. An anti-Tau antibody disclosed herein may also include one or two modified Fc polypeptides.
