ANTICORPS ANTI-TREM2 ET LEURS PROCEDES D'UTILISATION

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专利权人:

DENALI THERAPEUTICS INC.

发明人:

CHEN, HANG,DI PAOLO, GILBERT,HAO, RUI,LEWCOCK, JOSEPH W.,NUGENT, ALICIA A.,RAKHIT, RISHI,SHI, JU,SHUKLA, RINKAN,VAN LENGERICH, BETTINA,ZHANG, YIN,MOERKE, NATHAN,SRIVASTAVA, ANKITA

申请号：

CA3075285

公开号：

CA3075285A1

申请日:

2018.09.14

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

In one aspect, antibodies that specifically bind to a human triggering receptor expressed on myeloid cells 2 (TREM2) protein are provided. In some embodiments, the antibody increases levels of soluble TREM2 (sTREM2). In some embodiments, the antibody decreases levels of sTREM2. In some embodiments, the antibody enhances TREM2 activity. In some embodiments, the antibody inhibits TREM2 activity.

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