LIM, SUNGTAEK,林成泽,林成澤,HARRIS, KEITH JOHN,何林斯,STEFANY, DAVID,史坦利,GARDNER, CHARLES J.,葛德尼,CAO, BIN,曹斌,BOFFEY, RAY,宝飞儿,寶飛兒,GILLESPY, TIMOTHY A.,吉利飞,吉利飛,AGUIAR, JOACY C.,艾德尔,艾德爾,DYKE, HAZEL
申请号：
TW094135790
公开号：
TWI372751B
申请日:
2005.10.14
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
The present invention is directed to a compound of Formula (I) wherein Cy1, Cy2, L1, L2, and R1 are as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds according to Formula (I) in admixture with a pharmaceutically acceptable carrier, and a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like by administering to said patient a pharmaceutically effective amount of a compound according to Formula (I).本發明係關於一種式(I)之化合物；(I)；其中Cy1、Cy2、L1、L2和R1如本文所定義；一種包含療效量的一種或數種根據式(I)之化合物與一種藥學上可接受的載體混合之醫藥組成物；一種藉由給患者施用療效量的式(I)化合物，為患者治療由PGD2介導的疾病之方法，該疾病包括但不限於支氣管哮喘、慢性阻塞性肺炎(COPD)、過敏性鼻炎、過敏性皮炎、過敏性結膜炎、支氣管炎、全身性肥大細胞增多症和缺血性再灌注損傷。
