An isolatedLactobacillus paracaseistrain GMNL-133 deposited in the Biosource Collection and Research Center (BCRC) of the Food Industry Research and Development Institute (FIRDI) under the accession number of BCRC 910520 is disclosed. The isolatedLactobacillus paracaseistrain GMNL-133 is used for preparing a composition for use in treating the atopic dermatitis or other allergic diseases in an effective amount. And a composition for use in treating the atopic dermatitis or other allergic diseases comprising an effective amount of theLactobacillus paracaseistrain GMNL-133 is also disclosed.一種經分離之副乾酪乳酸桿菌株GMNL-133,寄存於台灣新竹食品工業研究發展研究所(Food Industry Research and Development Institute,FIRDI),寄存編號為BCRC 910520。前述副乾酪乳酸桿菌株GMNL-133可用於製造治療異位性皮膚炎或其他過敏疾病之組合物。以及,一種包括前述副乾酪乳酸桿菌株GMNL-133之組合物,且副乾酪乳酸桿菌株GMNL-133之含量可有效治療異位性皮膚炎或其他過敏疾病。