Quaternary salt compounds of Formula (I)or pharmaceutically acceptable forms thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.具下式(I)之四級鹽化合物或其醫藥上可接受之形式為CCR2拮抗劑,可用於預防、治療或改善有其需要的對象之由CCR2傳介之炎性症候群、失調症或疾病。