Provide formula (I) compound represented that can be used as CRTH2 receptor antagonist. Formula (I) compound represented can treat and prevent the other diseases that asthma, allergic rhinitis and atopic dermatitis and the prostaglandin D2 (PGD2) on CRTH2 receptor mediate with what.提供了可以作爲CRTH2受體拮抗劑的式(I)所示的化合物。式(I)所示的化合物可以用於治療和預防哮喘、變應性鼻炎和特應性皮炎以及在CRTH2受體上的前列腺素D2(PGD2)介導的其他疾病。