Isocyclic ammonia and its use in the treatment of high spread diseases such as cancer. Claim 1: a formula compound (1), wherein R 1 is Hal, La, oh, O (LA),NH y 2Fo NH (LA)N (LA)No.8322；CN OCN COOH COO (LA)Conh83222,Uh huh.CON (LA)NHCO (LA)NHCONH (LA)NHCONH₂,NHSO (LA)Xiaozhou, LtdOr single or double cycle, diluent or aromatic homosexual or heterosexual, of which 0, 1, 2, 3 or 4 N and / or O atoms and 4, 5 or 6, 7, 8, 9 or 10 skull atoms are irreplaceable or belong to the same species as Hal alone, orNH y 2Fo NH (LA)N (LA)No.8322；CN OCN COOH COO (LA)Conh83222,Uh huh.CON (LA)NHCO (LA)NHCONH (LA)NHCONH₂,a. Cho and / or CO (LA) or linear or periodic diffusion or non diffusion tar with 1, 2, 3, 4, 5, 6, 7 or 8 C atoms, of which 1 or 2 ch832222 groups can be replaced by O and / or group atoms；Uh huh.- I...-Nhco-o-ch = ch-y / or one of the ch groups can be divided into - N -；RA is h, or RA and R1,It is connected with each atom to form a heteromorphic ring composed of 3-7 members, 1-4 heteromorphic atoms independent of nitrogen, oxygen or sulfur, or a single heterocyclic ring composed of 5-6 members, 1-4 heteromorphic atoms independent of nitrogen and oxygen. A refers to a group of untreated tar or tree branches, consisting of 1, 2, 3, 4, 5 or 6 C atoms, of which 1-4 h atoms can be independently replaced by "Hal"； R 3 is h, or a group of linear tar.a. 1, 2, 3, 4, 5, 6, 7, 8, or 9 C atoms, one or two of which are ch832222 atomic groups can be replaced by o-o-nh group；and / or where one or two CH groups can be substituted with -N- and / or where 1, 2 or 3 H atoms can be substituted by Hal or OH； or R³ is a branched or unbranched alkyl group having 1, 2, 3, 4, 5 or 6 C atoms, which is substituted by a 3-6 membered ring, which may also be optionally substituted； R⁴ is aryl C₅₋₁₀,A C-8 ring composed of 3-8 saturated or partially unsaturated, an aperiodic ring composed of 3-7 members, consisting of 1-4 heteroatoms independent of nitrogen, oxygen or sulfur, Or a single ring compose
