NORCROSS, ROGER DAVID,GALLEY, GUIDO,PFLIEGER, PHILIPPE,GHELLAMALLAH, CÉDRIC
申请号：
ECSP13013072
公开号：
ECSP13013072A
申请日:
2013.12.09
申请国别(地区):
EC
年份:
2014
代理人:
摘要：
The invention refers to a compound of type A or iben formula, i.e. R1 is a substitute for hydrogen or phenyl, replaced by halogen gene, CN or low oxygen or low oxygen, replaced by halogen； R2 is hydrogen or low tar； R3 is hydrogen or low tar, or optionally replaced by one or more selected substitutes. In the halogen substitutes with lower halogen, cyanogen or methoxy content, either halogen is selected to replace pyridine with halogen or lower tar, or halogen is selected to replace halogen with lower tar, or pyridine is selected to replace pyridine with halogen,Cyanogen or lower tar substituted with halogen； R4 is hydrogen, lower tar or phenyl； Z is a linker, ch2-u-o, or a pharmaceutically acceptable acid salt. It has been found that a and IB compounds have a good receptor relationship with trace amines (taars),These compounds can be used to treat depression, anxiety, bipolar disorder, ADHD and other symptoms.Stress related diseases, psychoses such as schizophrenia and Parkinson's disease, neurodegenerative diseases such as Alzheimer's disease, epilepsy, migraine, hypertension, drug abuse and metabolic disorders, Examples include eating disorders, diabetes, diabetic complications, obesity, defatting, energy intake and digestion disorders, temperature disorders and dysfunction, homeopathy, sleep and cirrhosis disorders, and cardiovascular disease.La invención se refiere a compuestos de la fórmula IA o IBen las que:R1 es hidrógeno o fenilo opcionalmente sustituido por haló-geno, CN o alcoxi inferior o alcoxi inferior sustituido por halógeno； R2 es hidrógeno o alquilo inferior；R3 es hidrógeno o alquilo inferior o es fenilo opcionalmente sustituido por uno o más sustituyentes elegidos entre halógeno, ciano o alcoxi inferior sustituido por halógeno, o es piridinilo opcionalmente sustituido por halógeno o alquilo inferior sustituido por halógeno, o es pirimidinilo, opcionalmente sustituido por alquilo inferior sustituido por halógeno, o es pirazinilo, opcionalmente sustit
