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It is composed of aromatic amide containing nitrogen dioxide
专利权人:
ASTELLAS PHARMA INC.
发明人:
申请号:
ARP140102215
公开号:
AR096552A1
申请日:
2014.06.09
申请国别(地区):
AR
年份:
2016
代理人:
摘要:
A compound is provided as an effective agent for the treatment of breast cancer. 1. Characteristic 1: a compound in formula (1) or its salts, R1 is an arilo or isomer containing monocyclic nitrogen, each of which can be replaced by several groups in a group consisting of halogen, lower tar, lower halogen, lower tar, or halogen, lower tar, or - halogen tar. Lower, - CN, dimethamine and cycloquilo; X is ch, n or C; - 8315; - 8315; - 8315; - 8315; - 8315; - 8315; - 8315; - is a simple link, in the case of X is ch or N, and in the case of X is C, a double link, in this case, it is a cycle group selected from formula group (2),Y1 is cr688o n; Y2 is cr83055 or N, provided that Y1 and Y2 do not occur at the same time; r7491;R688a and r83055,Are they equal or different,H or halogen; r7495h or below asphalt; r758080 is lower asphalt; Y3 is ch or N; r74966 and r74977 are the same or different;H is h, halogen, lower asphalt; h or lower asphalt; y8308es or s; y83099 is ch or N; y8310s is ch or N; r7501es h or lower asphalt; R2 is h or lower asphalt; R3 and r830808;Are they equal or different,h. It is h, halogen, low tar or low tar, halogen low tar or halogen low cyclohexane, o-cn, or R3 and r83088. It can form 2.2-difluoro-1.3-benzodiazepine by combining with the benzene rings of R3 and r83088;Se provee un compuesto que es útil como un agente para el tratamiento de cáncer de mama. Reivindicación 1: Un compuesto de la fórmula (1) o una de sus sales, en la fórmula, R¹ es arilo o heteroarilo que contiene nitrógeno monocíclico, cada uno de los cuales puede estar sustituido con grupos seleccionados del grupo que consiste en halógeno, alquilo inferior, -O-alquilo inferior, halógeno-alquilo inferior, -O- halógeno-alquilo inferior, -CN, dimetilamino y cicloalquilo; X es CH, N o C; ⁻ ⁻ ⁻ ⁻ ⁻ es i) un enlace simple en el caso donde X es CH o N y ii) un enlace doble en el caso donde X es C; Y es un grupo cíclico seleccionado del grupo de fórmulas (2) aquí, Y¹ es CRʰ o N; Y² es CRⁱ o N, si
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