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Pyrazole derivatives
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
CEDRIC GHELLAMALLAH,PHILIPPE PFLIEGER,ROGER NORCROSS,GUIDO GALLEY
申请号:
ARP120102009
公开号:
AR088741A1
申请日:
2012.06.07
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
1. The compounds proposed in this proposal are the following compounds in formula (1) or (2): R 1 is hydrogen or benzene, which can be replaced by halogen, CN or low oxygen or low oxygen; R 2 is hydrogen or low tar; R3 is a hydrogen or lower hydrocarbon group, or an alternative to one or more alternatives selected from halogen, cyanogen or low oxygen, or an alternative pyridine, a halogen or lower hydrocarbon group, or a pyridine group, You can choose to replace halogen with a lower tar, or pyridine, or you can choose to replace halogen,a. Cyanogen or lower tar is replaced by halogen; r83088 is hydrogen, lower tar or phenyl; Z is link-ch832222-u-o;Or a medically acceptable acid salt. It has been found that the compounds of formula (1) and (2) have a good relationship with the receptors of trace amines (taars),Especially the terry These compounds can be used to treat depression, anxiety, bipolar disorder, attention deficit hyperactivity disorder (ADHD),Stress related diseases, psychoses such as schizophrenia and Parkinson's disease, neurodegenerative diseases such as Alzheimer's disease, epilepsy, migraine, hypertension, drug abuse and metabolic disorders, Examples include eating disorders, diabetes, diabetic complications, obesity, defatting, energy intake and digestion disorders, temperature disorders and dysfunction, homeopathy, sleep and cirrhosis disorders, and cardiovascular disease.La presente se refiere a compuestos de la fórmula (1) ó (2) en las que: R¹ es hidrógeno o fenilo opcionalmente sustituido por halógeno, CN o alcoxi inferior o alcoxi inferior sustituido por halógeno; R² es hidrógeno o alquilo inferior; R³ es hidrógeno o alquilo inferior o es fenilo opcionalmente sustituido por uno o más sustituyentes elegidos entre halógeno, ciano o alcoxi inferior sustituido por halógeno, o es piridinilo opcionalmente sustituido por halógeno o alquilo inferior sustituido por halógeno, o es pirimidinilo, opcionalmente sustituido por alquilo inferior sustituido por h
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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