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专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
JUERGEN WICHMANN,RAVI JAGASIA,ROLAND JAKOB-ROETNE
申请号:
MX2015013915
公开号:
MX2015013915A
申请日:
2014.03.31
申请国别(地区):
MX
年份:
2015
代理人:
摘要:
The present invention relates to compounds of general formula I wherein R1 is halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, lower alkoxy substituted by halogen or cyano; R2 is hydrogen, CF3 or lower alkyl; R3 is hydrogen, lower alkyl, lower alkenyl, lower alkinyl, heterocycloalkyl, lower alkyl substitueted by cyano, cyano, benzyl substituted by halogen, 2-oxa-6-aza-spiro[3.3]hept-6-yl or is lower alkoxy substituted by halogen; X is -CH2- or -CH2-CH2-; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. The compounds may be used for the treatment of schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder, Parkinson's disease, dementia, Alzheimer's disease, mild cognitive impairment, chemotherapy-induced cognitive dysfunction, Down syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of neuro-active drugs, such as alcohol, opiates, methamphetamine, phencyclidine and cocaine.La presente invención se refiere a compuestos de la fórmula general I: (ver formula) en la que: R1 es halógeno, alquilo inferior, alcoxi inferior, alquilo inferior sustituido por halógeno, alcoxi inferior sustituido por halógeno o ciano; R2 es hidrógeno, CF3 o alquilo inferior; R3 es hidrógeno, alquilo inferior, alquenilo inferior, alquinilo inferior, heterocicloalquilo, alquilo inferior sustituido por ciano, ciano, bencilo sustituido por halógeno, 2-oxa-6-aza-espiro[3.3]hept-6-ilo o es alcoxi inferior sustituido por halógeno; X es -CH2- o -CH2-CH2-; o a una sal de adición de ácido farmacéuticamente aceptable, a una mezcla racémica o a su e
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