您的位置: 首页 > 农业专利 > 详情页

专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
MATTHIAS NETTEKOVEN,ROGER NORCROSS,ALESSANDRA POLARA
申请号:
MX2013004547
公开号:
MX2013004547A
申请日:
2011.10.26
申请国别(地区):
MX
年份:
2013
代理人:
摘要:
The invention relates to compounds of formula (I) wherein R1 is hydrogen or lower alkyl R2 is hydrogen or is heteroaryl, optionally substituted by one or more halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen, cyano, S-lower alkyl, S(O)-lower alkyl, S(O)2-lower alkyl, C(O)-lower alkyl or C3-6-cycloalkyl R3 is hydrogen, halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen, cyano, S-lower alkyl, S(O)-lower alkyl, S(O)2-lower alkyl, C(O)-lower alkyl or C3-6-cycloalkyl R4 is hydrogen or lower alkyl (A) is phenyl or pyridinyl, wherein the N-atom may be in different positions X is a bond or CH(CF3)- Ar is aryl or heteroaryl, optionally substituted by one or more R3 or to a pharmaceutically suitable acid addition salt thereof. It has now been found that the compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The compounds may be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinsons disease, neurodegenerative disorders such as Alzheimers disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm and cardiovascular disorders.La invención se refiere a los compuestos de la fórmula (I) en donde R1 es hidrógeno o alquilo inferior R2 es hidrógeno o es heteroarilo, sustituido opcionalmente por uno o más halógenos, alquilo inferior, alquilo inferior sustituido por halógeno, alcoxi inferior, alcoxi inferior sustituido por halógeno, ciano, S-alquilo inferior, S(O)-alquilo inferior, S
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充