MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG
发明人:
LARS DR. BURGDORF,TATJANA DRA. ROSS,CARL DR. DEUTSCH
申请号：
ARP130100518
公开号：
AR090105A1
申请日:
2013.02.21
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
1. R1 in formula (1) is the compound of AR1 or het 1；R2 means ar2,Het,NH (CH) ArO (CH) ArNH (CH₂) ₙHet²,NHCONHA CONH o NR830808 for H or F； AR1 for phenyl, unsubstituted or monkey,di- or trisubstituted with Hal, A, [C (R³) ₂] ₙCN, (CH₂) ₙOH, (CH₂) ₙOA, (CH₂) ₙCOOH, (CH₂) ₙCOOA, S (O) ₘA, (CH₂) ₙHet³,CON (R)CONH (CH₂) ₙC (R³) ₂N (R³) ₂ and / or CONH (CH₂) ₚCH [(CH₂) ₙOR³] (CH₂) ₚOR³；Harp means phenyl, unsubstituted or cutedi- o trisustituido con A Hal (CH) OH (CH) OA (CH) NH(CH) NHA (CH) NASO₂NH₂,SO NHA SO NA(CH) CONH(CH) CONHA (CH) CONAC (R) N (R)CONH (CH) CH (CH) N (R) (CH) ORCONH (CH₂) ₚCH [(CH₂) ₙOR³] NHSO₂A, CONH (CH₂) ₚCH [(CH₂) ₙOR³] OR³,CONH (CH) (CH (OR) CH ORConhr8308；CONH (CH₂) ₚCH [(CH₂) ₙN (R³) ₂] Cyc, CONH (CH₂) ₙC (R³) ₂N (R³) ₂ and / or CONHC (R³) ₂ (CH₂) ₚOR³；Het¹ denotes benzo-1,3-dioxolyl or indazolyl, each of which is not substituted or monosubstituted with A； Het² denotes piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridyl, pyrimidinyl, triazolyl, tetrazolyl, oxadiazolyl, thiadiazolyl, pyridazinyl, pyrazinyl, quinolyl, isoquinolyl, benzimidazolyl, furopyridinyl or indazolyl, each of which is unsubstituted or mono-,di- o trisustituido con Hal NH (CH) HetA (CH) OH (CH) OA (CH) NH(ch83226a) (ch8345nha) (ch832222) - 8345na8322y / u = O； het Three Represents tetrazolidine or oxadiazolilo, each of which is not replaced or just a (CH 8322222) - 8345n832222；(ch8322nha) (ch8345nha) (ch83222y / u = O； hett83088n refers to pyridine or tetrahydrofuran, each of which is not replaced by a or nh832222 or only by a；R 3. Denotes h or tar with 1, 2, 3 or 4 C atoms； a refers to unbundled tar or resin with 1-10 C atoms, of which 1-7 H atoms can be replaced by F and / or Cl and / or 1-7 H atoms, or 1-2 non adjacent ch832222 groups can be replaced by O and / or NH, or cyclic tar with 3-7 C atoms, a. It may not have been replaced or completely replaced by Oh, nhcoa
