MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNG
发明人:
CHRISTOS DR. TSAKLAKIDIS,WOLFGANG DR. STAEHLE,BIRGITTA DR. LEUTHNER,PAUL DR. CZODROWSKI
申请号：
ARP130104165
公开号：
AR093461A1
申请日:
2013.11.13
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Estos compuestos son inhibidores de sintasa de cidos grasos y se pueden emplear inter alia para el tratamiento de enfermedades tales como c ncer enfermedades cardiovasculares lesi n del sistema nervioso central y diferentes formas de inflamaci n Reivindicaci n 1 Compuestos de la f rmula (1) en R1 means a, [C (R3) 832222], 8345ar1 or [C (R3) 8322228cyc； R2,R2 represents each independent,h. A, O [C (RM) 8322cyc； r8308 marks h, F, Cl, Br, oh, CN, no 832222；A OA SA SO Me COA CONHCONHA or CONA₂；X1,X2,X3,X830808 means that each of them is independent,a. Ch or N； a refers to the unbundled tar with 1-10 C atoms. In this case, two adjacent carbon atoms can form double-sided links and / or one or two adjacent CH and / or ch-8322 groups, which can be replaced by N or Y / or S atoms. In this case, 1-7 atoms of H can be replaced by r83099；CYC refers to cyclopentadiene of 3-7 C atoms that have not been replaced or replaced by O H, Hal or a alone； a refers to non branched tar or branch of 1-6 C atoms, in which 1-5 H atoms can be replaced by F； r83099 refers to F, CL or O H； R refers to phenyl, not replaced or monkey；Say...Three...4. Using Hal, a, or [C (R3) 832222het] to replace Tetrachlorobenzene；Ar1,C (R) ORC (R) N (R)No.8322；CN C (R) COORCON (R)C (R) N (R)N (R) COA NR SO A C (R) SO N (R)S (o) 8345a, or [C (R3) 832222]； 8344n (R3) 832222；Nhcooa, nhcon (R3) c8322 and / or COA； AR1 is phenyl or naphthalene, not substituted or monkey,Say...Three...a. Tetrabromodiphenyl ether substituted with Hal a, [C (R3) 832222] and 8346or und；C (R) N (R)No.8322；CN C (R) COORC (R) N (R)N (R) COA NR SO A C (R) SO N (R)S (o) 8345a, or [C (R3) 832222]； 8344n (R3) 832222；3. Coonha, nhcon (R3) and / or COA； R3 means h or tar without bunches or bulk 1-6 C atoms； het means saturated, unsaturated, unsaturated or aromatic single cycle or double cycle, with 1-4 n, O and / or S atoms, not replaced or justSay...Three...a. Using Hal, a, [C (R3) 832222], 8345oa, [C (R3) 8322n (R3) 8345n, [C (R3) 8322n],SRO,No.
