Verfahren zur Auflösung von Metronidazole mit Niacinamide und zwei Glykole und die erhaltene Lösung

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专利权人:

GALDERMA S.A.

发明人:

MALLARD, CLAIRE,BRZOKEWICZ, ALAIN

申请号：

EP10160846.1

公开号：

EP2204174B1

申请日:

2006.06.16

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

Solubilizing metronidazole comprises mixing an aqueous phase of metronidazole with glycolic niacinamide or its salts and at least two glycolic co-solvents, in the absence of cyclodextrin. Independent claims included for: (1) an aqueous metronidazole solution and obtained by the process； (2) an aqueous solution of metronidazole and niacinamide obtained by the process comprising at least two glycolic co-solvents； and (3) a pharmaceutical composition comprising the solution. ACTIVITY : Dermatological. MECHANISM OF ACTION : None given.

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